Methods and systems for hypobaric oxygenation using a membrane oxygenator are provided. The system and method allows analysis, control, or both, of a flow rate, a fluid composition, a pressure, a temperature, an oxygen fraction, a carbon dioxide fraction, a chemical composition, an anesthetic concentration, an anesthetic partial pressure, or a combination comprising at least one of the foregoing, at any of a number of places in the oxygenation system.
