METHODS AND APPARATUS FOR ACQUIRING IMAGE BASED BIOMARKERS SUITABLE FOR DIAGNOSIS OF NEURODEGENERATIVE DISEASES AND METHODS FOR DIAGNOSING NEURODEGENERATIVE DISEASES
The present invention relates to a method to acquire an image-based biomarker suitable for diagnosing neurodegenerative diseases； a method to provide information for diagnosing neurodegenerative diseases, an apparatus for predicting neurodegenerative diseases； and a computer program for the method to provide information for diagnosing neurodegenerative diseases and the apparatus for predicting neurodegenerative diseases. The method to acquire an image-based biomarker suitable for diagnosing neurodegenerative diseases comprises the following steps of: (a) collecting a magnetic resonance (MR) image and a positron emission tomography (PET) image of an object (k)； (b) computing a normalized cortex thickness value (Z^thickness_k) from the collected MR image, and a weighted value (W^NDD_k) regarding a pathological factor of neurodegenerative diseases from PET data； and (c) computing a cortex thickness value (Y^NDDweight_k) weighted with a pathological factor value regarding neurodegenerative diseases by multiplying Z^thickness_k and W^NDD_k.본 발명은 퇴행성 뇌질환의 진단에 적합한 이미지 기반 바이오 마커를 획득하는 방법, 퇴행성 뇌질환의 진단을 위한 정보의 제공 방법 및 퇴행성 뇌질환의 예측을 위한 장치 그리고 퇴행성 뇌질환의 진단을 위한 정보의 제공방법 및 퇴행성 뇌질환의 예측을 위한 장치를 위한 컴퓨터 프로그램에 관한 것이다.
