The present invention discloses pyridoindolobenzox- and thiazepine compositions of Formula 1, whereinA is —CH(R9)—X—, —XCH(R9)— —CO—X— or —X—CO— X is —O—, —S—, —SO—, or —SO2—. Y is a single bond or a double bond. D and E are independently —(CH2)n— and ‘n’ varies from 0 to 2. R1 to R9 are various electron donating, electron withdrawing, hydrophilic, or lipophilic groups selected to optimize the physicochemical and biological properties of compounds of Formula I.
