MEMORIAL SLOAN-KETTERING CANCER CENTER;The U.S.A. as Represented by the Secretary, Department Of Health and Human Services
发明人:
Prasad S. Adusumilli,Michel Sadelain,Dimiter S. Dimitrov,Yang Feng
申请号：
US15368278
公开号：
US10633441B2
申请日:
2016.12.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The presently disclosed subject matter provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to chimeric antigen receptors (CARs) that specifically target human mesothelin, and immunoresponsive cells comprising such CARs. The presently disclosed mesothelin-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.
