AVEDRO, INC.;HILL, Jason;ADLER, Desmond;FRIEDMAN, Marc D.;KAMAEV, Pavel;SHERR, Evan
发明人:
HILL, Jason,ADLER, Desmond,FRIEDMAN, Marc D.,KAMAEV, Pavel,SHERR, Evan
申请号：
USUS2019/064534
公开号：
WO2020/117974A1
申请日:
2019.12.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that that generates cross-linking in the cornea in response to exposure to an electromagnetic irradiation. This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which in which abnormal shaping of the cornea (e.g., thinning of the cornea, e.g., bilateral thinning of the cornea, e.g., bilateral thinning of the central, paracentral, or peripheral cornea； or steepening (e.g., bulging) of the cornea) contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition. Non-limiting examples of such diseases, disorders, or conditions include: (i) corneal ectatic disorders； (ii) vision conditions； and (iii) diseases, disorders, or conditions that are sequela or comorbid with any of the foregoing or any disclosed herein. More particular non-limiting examples of such diseases, disorders, or conditions include keratoconus, keratoglobus, pellucid marginal degeneration, corneal ectasia (e.g., post-operative ectasia, e.g., post-LASIK ectasia), Terrien's marginal degeneration, myopia, hyperopia, astigmatism, irregular astigmatism, and presbyopia.La présente invention concerne des entités chimiques (par exemple, un composé ou un sel et/ou un hydrate et/ou un promédicament pharmaceutiquement acceptable du composé) qui génère la réticulation dans la cornée en réponse à une exposition à un rayonnement électromagnétique. L'invention concerne également des compositions les contenant ainsi que d'autres procédés d'utilisation et de fabrication de celles-ci. Les entités chimiques sont utiles, par exemple, pour traiter un sujet (par exemple un être humain) ayant une maladie, un trouble ou un problème médical dans lequel une mise
