The present invention concerns immunoglobulins, such as antibodies, which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and modulate the interaction between OSM and gp130. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.本發明係關於免疫球蛋白(例如抗體),其可專一性鍵結制瘤素M(Oncostatin M;OSM),特別是人類OSM(hOSM),並調節OSM與gp130之間之相互作用。在典型實施例中,OSM係經醣基化。本發明亦係關於可調節OSM之位點II及位點III與彼等各自相互作用伴體之間之相互作用的抗體。本發明進一步揭示了醫藥組合物、篩檢及醫學治療方法。