The General Hospital Corporation d/b/a Massachusetts General Hospital;The Broad Institute, Inc.;Massachusetts Institute of Technology
发明人:
Edward Holson,Florence Fevrier Wagner,Michel Weiwer,Li-Huei Tsai,Stephen J. Haggarty,Yan-Ling Zhang
申请号：
US15234675
公开号：
US20180016282A9
申请日:
2016.08.11
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to compounds of formula (I):or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.
