The present invention provides lysine based compositions which include both an HIV antiviral or anti-retroviral agent and a compound of the formulawherein R1 may be, for example, (HO)2P(O)-, (NaO)2P(O)-, alkyl-CO- or cycloalkyl-CO-, wherein X and Y may be, for example, H, alkyl, cycloalkyl, F, Cl, Br, I or any of a range of other defined functional groups, wherein n is 3 or 4 and wherein R2 , R3 and R6 are as defined herein.