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DERIVADOS DE BENZOTIAZOL ANTIBACTERIANOS.
专利权人:
IDORSIA PHARMACEUTICALS LTD
发明人:
Christine SCHMITT,Jean-Philippe SURIVET,Azely MIRRE,Gaëlle CHAPOUX,Jean- Luc SPECKLIN
申请号:
MX2017006413
公开号:
MX2017006413A
申请日:
2015.11.18
申请国别(地区):
MX
年份:
2017
代理人:
摘要:
The invention relates to antibacterial compounds formula (I) wherein R1 is the group M, whereby M is one of the groups MA and MB represented below wherein A is a bond or C=C; R1A is H or halogen; R2A is H or halogen; R3A is H, alkoxy, hydroxyalkoxy, hydroxyalkyl, dihydroxyalkyl, 2-hydroxyacetamido, substituted cycloprop-1-yl or substituted oxetan-3-yl; and R1B is hydroxyalkyl, dihydroxyalkyl, aminoalkyl, dialkylaminoalkyl, substituted cycloprop-1-yl, substituted cyclobutan-1-yl, substituted oxetan-3-yl, 3-hydroxythietan-3-yl, substituted azetidin-3-yl, trans-(cis-3,4-dihydroxy)-cyclopent-1-yl, 3-hydroxymethylbicyclo[1,1,1]pentan-1-yl, 4-hydroxytetrahydro-2H-pyran-4-yl, (3R,6S)-3-aminotetrahydro-2H-pyran-6-yl, piperidin-4-yl or 1-(2-hydroxyacetyl)piperidin-4-yl; and salts thereof.La invención se refiere a compuestos antibacterianos de la fórmula I, en donde R1 es el grupo M, en donde M es uno de los grupos MA y MB representados a continuación, en donde A es un enlace o C=C; R1A es H o halógeno; R2A es H o halógeno; R3A es H, alcoxi, hidroxialcoxi, hidroxialquilo, dihidroxialquilo, 2-hidroxiacetamido, cicloprop-1-ilo sustituido u oxetan-3-ilo sustituido; y R1B es hidroxialquilo, dihidroxialquilo, aminoalquilo, dialquilaminoalquilo, cicloprop-1-ilo sustituido, ciclobutan-1-ilo sustituido, oxetan-3-ilo sustituido, 3-hidroxitietan-3-ilo, azetidin-3-ilo sustituido, trans-(cis-3,4-dihidroxi)-ciclopent-1-ilo, 3-hidroximetilbiciclo[1 ,1,1]pentan-1-ilo, 4-hidroxitetrahidro-2H-piran-4-ilo, (3R, 6S)-3-aminotetrahidro-2H-piran-6-ilo, piperidin-4-ilo o 1-(2-hidroxiacetil)piperidin-4-ilo; y sales de los mismos.
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中国工程科技知识中心
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http://www.ckcest.cn/home/
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