Boone, Thomas C.,Oliner, Jonathan D.,Lee, Eunkyung
申请号：
ES13185473
公开号：
ES2660381T3
申请日:
2009.02.20
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Isolated monoclonal antibody comprising a heavy chain variable domain and a light chain variable domain, wherein said heavy chain comprises 3 CDR and said light chain comprises 3 CDR, wherein the sequences of said CDRs of said antibody are selected from the group consisting of: (a) SEQ ID NO: 18, 26, 32 of the HC plus SEQ ID NO: 19, 27, 33 of the LC, (b) SEQ ID NO: 18, 26, 34 of the HC plus SEQ ID NO: 19, 27, 33 of the LC, (c) SEQ ID NO: 18, 26, 35 of the HC plus SEQ ID NO: 20, 27, 36 of the LC, (d) SEQ ID NO: 18 , 26, 37 of the HC plus SEQ ID NO: 19, 27, 33 of the LC, (e) SEQ ID NO: 18, 26, 38 of the HC plus SEQ ID NO: 19, 27, 33 of the LC, (f) SEQ ID NO: 18, 26, 35 of the HC plus SEQ ID NO: 19, 27, 33 of the LC, (g) SEQ ID NO: 18, 26, 34 of the HC plus SEQ ID NO: 21 , 27, 33 of the LC, (h) SEQ ID NO: 18, 28, 39 of the HC plus SEQ ID NO: 19, 27, 33 of the LC, (i) SEQ ID NO: 18, 26, 34 of the HC plus SEQ ID NO: 22, 27, 33 of the LC, (j) SEQ ID NO: 18, 26, 32 of the HC plus SEQ I D NO: 22, 27, 33 of the LC, (k) SEQ ID NO: 18, 29, 39 of the HC plus SEQ ID NO: 19, 27, 33 of the LC, (l) SEQ ID NO: 18, 26, 34 of the HC plus SEQ ID NO: 23, 27, 33 of the LC, (m) SEQ ID NO: 18, 26, 35 of the HC plus SEQ ID NO: 20, 27.40 of the LC, ( n) SEQ ID NO: 18, 26, 32 of the HC plus SEQ ID NO: 21, 27, 33 of the LC, (o) SEQ ID NO: 18, 26, 35 of the HC plus SEQ ID NO: 24, 27, 33 of the LC, (p) SEQ ID NO: 18, 26, 35 of the HC plus SEQ ID NO: 21, 27, 33 of the LC, (q) SEQ ID NO: 18, 26, 35 of the HC plus SEQ ID NO: 23, 27, 33 of the LC, (r) SEQ ID NO: 18, 26, 34 of the HC plus SEQ ID NO: 20, 30, 33 of the LC, (s) SEQ ID NO : 18, 26, 34 of the HC plus SEQ ID NO: 25, 27, 33 of the LC, (t) SEQ ID NO: 18, 26, 35 of the HC plus SEQ ID NO: 20, 30, 33 of the LC, (u) SEQ ID NO: 18, 26, 34 of the HC plus SEQ ID NO: 20, 27, 40 of the LC, and (v) SEQ ID NO: 18, 26, 34 of the HC plus SEQ ID NO: 20, 31, 33 of the LC； wherein said antibody specifically binds to at least one of the Ang1 and Ang2 ligands
