The present specification describes systems and methods for detecting anocclusion in a tubing carrying a patient'sblood through a manifold and into a dialyzer in a dialysis system. Acontroller measures pressures value of the blood at apredetermined point after exiting the manifold and before entering thedialyzer, calculates a historical running average, calculates a weightedsum of the most recent pressure values, and determines whether to trigger anocclusion alarm based on a function of the historicalrunning average and the weighted sum of the most recent pressure values.
