CHILDRENS HOSPITAL OF EASTERN ONTARIO RESEARCH INSTITUTE INC.;CHILDREN'S HOSPITAL OF EASTERN ONTARIO RESEARCH INSTITUTE INC.
发明人:
STOJDL, DAVID F.
申请号：
CA2872045
公开号：
CA2872045A1
申请日:
2012.06.07
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present disclosure concerns an oncolytic virus for the treatment of cancer, such as in brain cancer, for example glioblastoma. The oncolytic virus may exhibit reduced levels of neurotoxicity. The oncolytic virus may be an isolated viral particle capable of producing a cDNA polynucleotide that includes a sequence according to SEQ ID NO: 1 when the virus is in a host cell. The oncolytic virus may be an isolated viral particle that includes an RNA polynuclotide that includes a sequence according to SEQ ID NO: 2. The oncolytic virus may be an isolated viral particle having a genome that includes open reading frames that encode: proteins having sequences comprising SEQ ID NOs: 3, 4, 5, 6 and 7； or variants thereof.
