An active particle temperature difference slow-release structure, which includes a substrate; a coating layer, disposed on one side of the substrate, the coating layer is composed of a plurality of particles, the particles include: a shell with at least one accommodating space; And a filler is arranged in the accommodating space. With the above structure, when the casing is squeezed or the temperature is raised to a certain level, the casing will break to cause the filler to flow out, thereby achieving that the filler is not actively released under normal conditions, and the effect of effective preservation is achieved.一種活性微粒溫差緩釋結構,其包含一基材;一塗料層,設置於該基材一面上,該塗料層由複數微粒組成,該等微粒包含:一殼體,具有至少一容置空間;及一填充物,設置於該容置空間內。藉由上述結構,該殼體受到擠壓或溫度提升至一定層度時,該殼體會產生破裂使填充物流出,藉此達到一般狀態下不主動釋放填充物,達到有效保存之功效。