БИРАН Рой (US),КЛОД Чарльз Д. (US),КЛИК Роберт Л. (US),ДРАМХЕЛЛЕР Пол Д. (US),ЛИ Мэй (US),МАРДИРОСЯН Нора (US)
申请号：
RU2012115097/15
公开号：
RU2012115097A
申请日:
2010.09.16
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A medical substrate, comprising: heparin particles (entities) bound to the substrate through at least one heparin molecule, the bound heparin particles being sensitive to heparinase. 2. The medical substrate according to claim 1, wherein the heparin particles comprise at least one heparin molecule and at least one core molecule. Heparin particles, comprising: at least one heparin molecule and at least one scaffold molecule such that when heparin particles are bound to the substrate through at least one heparin molecule, these heparin particles will be sensitive to heparinase. 4. The medical substrate or heparin particles according to claim 2 or 3, wherein the skeleton molecule is cyclic, linear, branched, tree-like, T-shaped, Y-shaped or star-shaped. The medical substrate or heparin particles according to claim 2 or 3, wherein the scaffold molecule is selected from the group consisting of proteins, polypeptides, hydrocarbons, polysaccharides, aminoglycosides and polymers, optionally: the protein is selected from the group consisting of albumin, colistin and polylysine, or the polysaccharide is selected from the group consisting of cyclodextrin, cellulose and chitosan, or the polymer is selected from the group consisting of polyethylene glycol (PEG) and tetrafluoroethylene copolymers. 6. The medical substrate or heparin particles according to claim 1 or 3, wherein the heparin comes from a bovine or porcine source. The medical substrate or heparin particles according to claim 1 or 3, wherein after treatment with heparinase, heparin or its fragments are not detected on the substrate, and optionally heparin or its fragments are detected1. Медицинский субстрат, включающий:гепариновые частицы (entities), связанные на субстрате через по меньшей мере одну молекулу гепарина, причем связанные гепариновые частицы чувствительны к гепариназе.2. Медицинский субстрат по п.1, в котором гепариновые частицы содержат по меньшей мере одну молекулу гепарина и по меньшей мере одну кар
