HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUMFÜR GESUNDHEIT UND UMWELT (GMBH)
发明人:
Reinhard ZEIDLER,Bettina VON NEUBECK,Regina FEEDERLE,Stefanie HAUCK
申请号：
US16614314
公开号：
US20200148781A1
申请日:
2018.05.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to improved anti-CD73 antibodies which, in comparison to prior art anti-CD73 antibodies bind to a membrane-bound form of CD73 protein having cancer-promoting role and inhibit its enzymatic activity, while essentially not inhibiting a soluble form of CD73 protein involved in cardioprotection. The present invention further relates to methods of generation of such specific anti-CD73 antibodies and uses thereof including uses as medicaments and in methods for treatment, amelioration, prophylaxis and diagnostics of cancer.
