The invention relates to a use of resveratrol for manufacturing oral care compositions for anti-oral submucous fibrosis. It comprises applying an effective dose of the resveratrol to a subject in need to reduce oral submucous fibrosis caused by the fibrotic buccal mucosal fibroblasts.本發明係有關於一種白藜蘆醇於製備抗口腔黏膜下纖維化症之口腔保健組合物的用途,其係施予一有效劑量之白藜蘆醇(Resveratrol)於一所需個體,以改善由纖維化頰黏膜纖維母細胞(fibrotic buccal mucosal fibroblast)引起的口腔黏膜下纖維化症(oral submucous fibrosis)。