For example as for this invention, anesthetic Characteristic chemical compound (non opioido anesthetic peptide, NOP agonisuto or N/OFQ) it is due to cranial facial mucous membrane dosage, manner and the constituent for painfully remedy are offered. Dosage inside the nasal cavity of the anesthetic peptide of the specification of N/OFQ and the like brings the wide area analgesic effect. With one feature, as for this invention, the fact that effective dosage of NOP agonisuto is prescribed to the individual which needs that with cranial facial mucous membrane dosage is included, manner for painfully remedy is offered. With execution configuration of part, as for remedy, the Y form nerve painful and somatic painfully, nervous fault Characteristic painfully, disposal painfully or the internal organs painfully remedy is included. With execution configuration of part, as for remedy, acuteness painfully or chronic painfully remedy is included. With execution configuration of part, painfully the cranial face painfully or the head painfully is.本発明は、鎮痛性化合物(例えば非オピオイド鎮痛ペプチド、NOPアゴニストまたはN/OFQ)の頭蓋顔面粘膜投与による疼痛の治療のための方法および組成物を提供する。N/OFQなどの特定の鎮痛ペプチドの鼻腔内投与は、広域鎮痛効果をもたらす。 一態様では、本発明は、それを必要とする個体にNOPアゴニストの有効用量を頭蓋顔面粘膜投与によって投与することを含む、疼痛の治療のための方法を提供する。一部の実施形態では、治療は、三叉神経疼痛、体性疼痛、神経障害性疼痛、処置の疼痛または内臓疼痛の治療を含む。一部の実施形態では、治療は、急性疼痛または慢性疼痛の治療を含む。一部の実施形態では、疼痛は頭蓋顔面疼痛または頭部疼痛である。
