KIM, HONG-JIN,LEE, NA GYONG,CHO, YANG-JE,JANG, JIN-WOOK,KIM, HYOUNG JIN,KIM, KWANG SUNG
申请号：
EP09846240
公开号：
EP2444103A4
申请日:
2009.10.20
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention relates to a pharmaceutical vaccine composition for a human cervical cancer, comprising: (a) (i) a L1 virus-like particle (VLP) of human papillomavirus (HPV) type 16, a L1 VLP of HPV type 18, or a combination thereof； and (ii) a deacylated non-toxic lipooligosaccharide (LOS)； and (b) a pharmaceutically acceptable carrier； and a method for preparing a human papillomavirus (HPV) L1 virus-like particle (VLP). The pharmaceutical vaccine composition of the present invention is in both Th1-type immune response (cellular immunity) and Th2-type immune response (humoral immunity) against HPV more excellent than Cervrix „¢ and Gardasil „¢ , exhibiting a superior efficacy as a vaccine for a human cervical cancer.
