Disclosed are methods of treating fibrosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of an ACK inhibitor (e.g., a BTK inhibitor, such as for example an irreversible BTK inhibitor, such as for example, ibrutinib).本發明揭示治療患者中纖維化之方法,其包括將治療有效量之ACK抑制劑(例如,BTK抑制劑,諸如例如不可逆BTK抑制劑,諸如例如依魯替尼(ibrutinib))投與有其需要之患者。