FAHAM, MALEK,CARLTON, VICTORIA,MOORHEAD, MARTIN,ZHENG, JIANBIAO,ASBURY, THOMAS
申请号：
EP12844825
公开号：
EP2773773A4
申请日:
2012.10.25
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The invention includes a method for determining the disease status of an individual suffering from ankylosing spondylitis by monitoring the individual's T-cell repertoire for the presence and/or level of clonotypes encoding T-cell receptor chains with segments identical to and/or related to the peptide LCASSLEASGSSYNEQFFGPGTRLTV (SEQ ID NO: 1) or the peptide VYFCASSDSSGSTDTQYFGPGTRLTV (SEQ ID NO: 2). The invention also includes therapeutic antibodies specific for these peptides for ameliorating the effects of ankylosing spondylitis.
