PROBLEM TO BE SOLVED: To provide a hollow-fiber membrane type blood purification device having improved antioxidative performance and favorable water permeability, blood compatibility, and economic rationality.SOLUTION: The hollow-fiber membrane type blood purification device has a container filled with hollow fiber membranes, the hollow fiber membrane including hydrophobic polymer, hydrophilic macromolecule, and fat-soluble vitamin. When the inside of an inner circle with a radius 1/2 of that of the hollow fiber membrane bundle is defined as a central part and a part not included in the central part is defined as an outer periphery part, an amount of the fat-soluble vitamin per 1 m2 of the hollow-fiber membrane inner surface of the central part is more than an amount of the fat-soluble vitamin per 1 m2 of the hollow-fiber membrane inner surface of the outer peripheral part, and an amount of the fat-soluble vitamin per 1 m2 of the hollow-fiber membrane inner surface of the central part is not less than 20 mg/m2 and not more than 300 mg/m2.COPYRIGHT: (C)2015,JPO&INPIT【課題】抗酸化性能を向上させ、かつ良好な透水性能及び血液適合性能、経済合理性を有する中空糸膜型血液浄化装置を提供すること。【解決手段】中空糸膜を容器に充填した中空糸膜型血液浄化装置であって、該中空糸膜は、疎水性高分子、親水性高分子及び脂溶性ビタミンを含み、中空糸膜束の1/2半径の内円内を中心部、中心部に入らない部分を外周部とした際に、中心部の中空糸膜内表面1m2あたりの脂溶性ビタミン量が外周部の中空糸膜内表面1m2あたりの脂溶性ビタミン量よりも多く、中心部の中空糸膜内表面1m2あたりの脂溶性ビタミン量が20mg/m2以上300mg/m2以下である中空糸膜型血液浄化装置。【選択図】なし
