A composition comprising the extracts of Galla Rhois and Moutan Cortex Radicis is provided to improve antibacterial and antiviral activity, minimize damage of conventional antibiotics including antibiotic remaining and antibiotic resistance, and inhibit toxicity or side effects in employment, so that the composition is useful for prevention and treatment of porcine respiratory and digestive disease in mammals. A composition for prevention and treatment of porcine respiratory and digestive disease in mammals including human comprises 0.1-50 wt.% of the extracts of Galla Rhois and Moutan Cortex Radicis in a mixing ratio of 1-3:1, which are prepared by extracting them with a solvent selected from water, C1-C4 lower alcohol and a mixture thereof, wherein the porcine respiratory disease is selected from porcine Pasteurella pneumonia, porcine Mycoplasma pneumonia, pircine atrophic rhinitis, porcine pleuropneumonia, Glasser's disease, PRRS(porcine reproductive and respiratory syndrome), PMWS(post-weaning multisystemic wasting syndrome) and PRDC(porcine respiratory disease complex)； and the porcine digestive disease is selected from Yersinia enteritis, proliferative enteropathies, colitis, swine dysentery, non-infectious colitis, Salmonella enteritis, Escherichia coli diarrhea, TGE(transmissible gastroenteritis) and PED(porcine epidemic diarrhea). Further, infectious bacteria of the porcine respiratory disease are selected from Mannheimia haemolytica, Haemopilus somnus, Pasteurella multocida, Mycoplasma hyopheumonia and Actinobacillus pleuropneumonia.본 발명은 항균 및 항바이러스 활성을 갖는 조성물에 관한 것으로, 상세하게는 오배자 및 목단피 추출물을 유효성분으로 함유하는 본 발명의 조성물은 돼지 호흡기 또는 소화기 질환에 대한 뛰어난 항균 및 항바이러스 효과를 나타내므로, 상기 질환의 예방 및 치료를 위한 약학 조성물 및 건강기능식품으로 유용하게 이용될 수 있다.
