The disclosure provides a method to prevent, control, and/or treat opioid induced dysfunctions comprising administering to a patient in need a guanylate cyclase receptor agonist (GCRA) peptide. Compositions comprising guanylate cyclase receptor agonist (GCRA) peptides, methods of making, and methods of treatment are also disclosed. Further disclosed are the guanylate cyclase receptor agonist (GCRA) peptide and opioid formulated in the same composition.
