ANTIBODY-DRUG CONJUGATE WITH A TUBULYSIN ANALOG WARHEAD HAVING A STABILIZED ACETATE GROUP IN THE TUV SUBUNIT

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专利权人:

BRISTOL-MYERS SQUIBB COMPANY

发明人:

Ian S. Young,Sha Lou,Sanjeev Gangwar

申请号：

US16437047

公开号：

US20190388553A1

申请日:

2019.06.11

申请国别(地区):

US

年份:

2019

代理人:

摘要：

In antibody-drug conjugates having tubulysin analog as the warhead, according to formula (III)the acetate group in the Tuv subunit (dotted box) demonstrates improved stability against hydrolytic cleavage.

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中国工程科技知识中心

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