做為週期素依賴型激酶（ＣＤＫ）抑制劑之２－Ｈ－吲唑衍生物及其醫療用途农业专利-农业专业知识服务系统

发明人:: GRECO, MICHAEL NICHOLAS,格雷科　迈克尔　尼古拉斯,格雷科　邁克爾　尼古拉斯,COSTANZO, MICHAEL JOHN,科斯坦佐　迈克尔　约翰,科斯坦佐　邁克爾　約翰,PENG, JIRONG,彭　继荣,彭　繼榮,WILDE, VICTORIA LYNN,王尔德　维多利亚　林恩,王爾德　維多利亞　林恩,ZHANG, DON,张　东,張　東,格雷科迈克尔尼古拉斯,格雷科邁克爾尼古拉斯,科斯坦佐迈克尔约翰,科斯坦佐邁克爾約翰,彭继荣,彭繼榮,王尔德维多利亚林恩,王爾德維多利亞林恩,张东,張東

摘要：: Indazole compounds of formula (I) as cyclin-dependent kinase (CDK) and cell-proliferation inhibitors, and therapeutic uses and methods of preparation thereof, are disclosed. These compounds, and pharmaceutically acceptable salts, solvates, prodrugs, and pharmaceutical compositions thereof, are useful for treating diseases and disorders associated with activity of cyclin-dependent kinases, in particular CDK4/6, including but not limited to various cancers and inflammation-related diseases or conditions.本發明揭示做為週期素依賴型激酶(CDK)及細胞增殖抑制劑之式(I)之吲唑化合物及其醫療用途及製備方法。此等化合物及其醫藥學上可接受之鹽、溶劑合物、前藥及醫藥組合物適用於治療與週期素依賴型激酶，尤其CDK4/6之活性關聯之疾病及病症，該等疾病及病症包含(但不限於)各種癌症及炎症相關之疾病或病狀。