Alison Helena Goodall,Sarah Margaret Taylor,Greg Francis Walker
申请号：
US13408897
公开号：
US20130029913A1
申请日:
2012.02.29
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Therapeutic agents suitable for use as artificial platelets are described. The agents comprise a fibrinogen binding precursor bound to an insoluble carrier, wherein the fibrinogen binding precursor can be converted by a wound site specific agent, such as thrombin, to a fibrinogen binding component bound to the carrier. The fibrinogen binding component has increased ability to bind fibrinogen compared to the fibrinogen binding precursor. The agents may be used to treat patients with deficiencies in their own platelets, such as hereditary or acquired defects of platelet numbers (thrombocytopenia) or function (thrombasthenia).
