PROBLEM TO BE SOLVED: To provide a prophylactic and/or therapeutic agent for Trk-related disease.SOLUTION: Provided is 1-{2-[4-(2-Amino-5-chloro-3-pyridinyl)phenoxy]-5-pyrimidinyl}-3-[2-(methylsulfonyl)-5-(trifluoromethyl)phenyl]urea, p-toluene sulfonate which is a compound having a Trk-selective inhibitory activity, and having a persistent inhibition of NGF vascular hyperpermeability, and in addition to having no drug interactions, further having excellent solubility and absorptivity for free bases.SELECTED DRAWING: None【課題】Ｔｒｋ関連疾患の予防および／または治療剤の提供。【解決手段】Ｔｒｋ選択的な阻害活性を有し、ＮＧＦ血管透過性亢進を持続的に抑制し、薬物相互作用を有さないことに加え、さらに遊離塩基に対して溶解性、吸収性に優れた化合物である、１－｛２－［４－（２－アミノ－５－クロロ－３－ピリジニル）フェノキシ］－５－ピリミジニル｝－３－［２－（メチルスルホニル）－５－（トリフルオロメチル）フェニル］ウレア、ｐ－トルエンスルホン酸塩。【選択図】なし
