PROTOZOÁRIO MODIFICADO QUE EXPRESSA PELO MENOS DUAS PROTEÍNAS DE SUPERFÍCIE VARIÁVEL (VSP), UMA VACINA QUE COMPREENDE O MESMO E PROCEDIMENTOS, UTILIZAÇÕES E MÉTODOS DOS MESMOS
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET);UNIVERSIDAD CATÓLICA DE CÓRDOBA (UCC)
发明人:
HUGO DANIEL LUJAN
申请号：
PT09799724
公开号：
PT2364156T
申请日:
2009.12.02
申请国别(地区):
PT
年份:
2018
代理人:
摘要：
Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-polymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism.
