SHIN NIPPON BIOMEDICAL LABORATORIES, LTD.;WAVE LIFE SCIENCES JAPAN
发明人:
GEMBA, TAKEFUMI
申请号：
CA2879066
公开号：
CA2879066A1
申请日:
2013.07.12
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
[Problem] The purpose of the present invention is to provide: a stereoisomer of a novel CpG oligonucleotide, which has excellent stability； and a CpG oligonucleotide which has a capability of producing interferon-a (IFNa). [Solution] The present invention relates to an oligonucleotide which contains two to four sequences each represented by the formula 5'-X1X2CpGX3X4-3' (formula (I)) and has a length of 14 to 32 nucleotides. In formula (I), CpG represents a non-methylated CpG residue having a phosphate skeleton modification, X1X2 represents any one of AA, AT, GA and GT, and X3X4 represents any one of TT, AT, AC and CG. The oligonucleotide has at least one phosphate skeleton modification at an S-form stereoisomer located at a site other than the CpG.
