A cleaning cap for a medical implement having a male protrusion. The cleaning cap includes a housing defining an inner cavity defined by an inner wall and distal end that encloses the inner cavity, and an opening opposite the distal end. The inner wall has a recess near the opening to the housing. The recess has a diameter that is greater than a diameter of the inner wall near the recess. The cap further includes a movable piston having a forward nose and rearward end surrounded by a flexible flange that extends outward and toward the opening to abut the inner wall near the recess of the housing to maintain a cleaning solution in the inner cavity prior to receipt of the male protrusion into the inner cavity. The rearward end of the movable piston configured to couple with a distal end of the male protrusion to move the piston toward a distal end of the housing opposite the opening of the housing to provide a portion of the cleaning solution to the male protrusion.