Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof

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专利权人:

Kazunori Kataoka

发明人:

Kazunori Kataoka,Nobuhiro Nishiyama,Atsushi Ishii,Yasuki Kato,Kanjiro Miyata,Hyunjin Kim,Hiroyasu Takemoto

申请号：

US12922116

公开号：

US08431545B2

申请日:

2009.03.06

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polyamino acid chain block, wherein the hydrophilic polymer chain block is covalently bound to one end of the main chain of the polyamino acid chain block, and the hydrophobic group is covalently bound to the side chains of not less than 10% and not greater than 70% of amino acid repeating units in the polyamino acid chain block. This block copolymer forms a stable aggregate with siRNA, a small-molecule nucleic acid, under a physiological condition.

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