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PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THEM
专利权人:
ЭББОТ ЛЭБОРЕТРИЗ (US)
发明人:
ФРАУНХОФЕР Вольфганг (US),БАРТЛЬ Анника (DE),КРАУЗЕ Ханс-Юрген (DE),ЧЕПЕ Маркус (DE),КАЛЕТА Катарина (DE)
申请号:
RU2010126658/15
公开号:
RU2010126658A
申请日:
2008.11.28
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. An aqueous composition comprising protein and water, where the composition has a conductivity of less than about 2.5 mS / cm and the protein has a molecular weight (MW) of more than about 47 kDa. ! 2. The composition according to claim 1, in which a) the protein has an MC of more than about 57 kDa, or more than about 100 kDa, or more than about 150 kDa, or more than about 200 kDa, or more than about 250 kDa; ! b) the composition has a conductivity of less than about 2 mS / cm, or less than about 1.5 mS / cm, or less than about 1 mS / cm, or less than about 0.5 mS / cm; ! c) where the protein concentration is at least about 10 μg / ml, and water, where the composition has a conductivity of less than about 2 mS / cm; not necessary ! wherein the protein concentration is at least about 1 mg / ml, or at least about 10 mg / ml, or at least about 50 mg / ml, or at least about 100 mg / ml, or at least about 150 mg / ml, or at least about 200 mg / ml, or more than about 200 mg / ml; not necessary ! where the composition has a conductivity of less than about 1 mS / cm or less than about 0.5 mS / cm, or! d) where the protein is present in a concentration of at least about 50 mg / ml and water, where the composition has an osmolality not exceeding about 30 mOsmol / kg; not necessary ! the osmolality of the composition does not exceed about 15 mOsmol / kg, optional! where the protein concentration is at least about 100 mg / ml, or at least about 150 mg / ml, or at least about 200 mg / ml, or the protein concentration is greater than about 200 mg / ml or! e) where the protein has a hydrodynamic diameter (Dh) that is at least about 25% less than the Dh of the protein in the buffer solution at a given concentration; not necessary !1. Водная композиция, включающая белок и воду, где композиция имеет проводимость меньше примерно 2,5 мСм/см, и белок имеет молекулярную массу (MW) больше примерно 47 кДа. ! 2. Композиция по п.1, в которой а) белок имеет Мц больше примерно 57 кДа, или
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