KIZHAKKEDATHU, Jayachandran,MORRISSEY, James H.,TRAVERS, Richard J.,SHENOI, Rajesh,KALATHOTTUKAREN, Manu Thomas
申请号：
EP15799684
公开号：
EP3148553A4
申请日:
2015.05.29
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Provided herein are polymers and methods for their use in binding a phosphate containing biological macromolecules. Specifically, the methods and uses provided herein may be used to inhibit thrombin binding to polyphosphate or as an antithrombotic agent for the treatment of stroke, acute coronary syndrome, pulmonary embolism, atrial fibrillation, venous and arterial thromboembolism, disseminated intravascular coagulation (DIC), deep-vein thrombosis (DVT), peripheral artery disease, trauma-induced coagulopathy, extracorporeal circulation, cancer-associated thrombosis, sepsis, septic shock, Systemic Inflammatory Response Syndrome (SIRS), or inflammation.
