Idenix Pharmaceuticals LLC;Universitą Degli Studi di Cagliari
发明人:
SOMMADOSSI, Jean-Pierre,LA COLLA, Paolo,STANDRING, David,BICHKO, Vadim,QU, Lin
申请号：
LT03796412
公开号：
LT1576138T
申请日:
2003.11.17
申请国别(地区):
LT
年份:
2017
代理人:
摘要：
The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2&prime；-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from seine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT (Sequence ID No. 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.
