Tocotrienol esters

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专利权人:

Khalid A. El Sayed

发明人:

Khalid A. El Sayed,Paul W. Sylvester

申请号：

US13021361

公开号：

US08969303B2

申请日:

2011.02.04

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Esters of tocotrienols having pharmacological activities pertinent to the treatment of breast cancer and other forms of cancer are disclosed herein. Among those compounds is (Z)-4-oxo-4-((R)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)chroman-6-yloxy)but-2-enoic acid. Tocotrienol esters were used to inhibit the growth and migration of +SA mammary epithelial cells and highly metastatic human breast cancer MDA-MB-231 cells respectively.

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