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Polypeptide sequence involved in the modulation of the immunosuppressive effect of viral proteins
专利权人:
Martial Renard
发明人:
Martial Renard,Marianne Mangeney,Thierry Heidmann
申请号:
US11547399
公开号:
US08178657B2
申请日:
2005.03.30
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-modulatory sequence) when it substitutes the homologous sequence of the viral protein or fragment, the polypeptide including the minimum following consensus amino acid sequence:X1Y9Y10Y11CY12X2 wherein, X1 and X2 are selected to impact on the immunosuppressive properties, and Y9 to Y12 represent variable amino acid residues.
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