Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC, including rheumatoid arthiritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, Charcot Marie Tooth syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, global ischemia, ulcerative colitis, Crohn’s disease, immune thrombocytopenic purpura, atherosclerosis, systemic lupus erythematosis, myelopreparation for autologous transplantation, transplant rejection, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, type I diabetes, acute pain, inflammatory pain, neuropathic pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastoma, neurofibromatosis, osteolytic bone metastases, brain metasteses, gastrointestinal stromal tumors, and giant cell tumors.本文描述化合物及其鹽、其調配物、其結合物、其衍生物、其形式及其用途。在某些態樣及具體實例中，所述化合物或其鹽、其調配物、其結合物、其衍生物、其形式對Fms、Kit、Flt3、TrkA、TrkB及TrkC激酶蛋白中之一或多者具有活性。本文亦描述使用其治療疾病及病狀之方法，該等疾病及病狀包括與Fms、Kit、Flt3、TrkA、TrkB及TrkC中之一或多者之活性有關的疾病及病狀，包括類風濕性關節炎、骨關節炎、骨質疏鬆症、假體周圍骨溶解、全身性硬化症、脫髓鞘症、多發性硬化症、夏馬杜氏症候群、肌萎縮性側索硬化症、阿茲海默氏病、帕金森氏病、全腦缺血、潰瘍性結腸炎、克羅恩氏病、免疫血小板減少性紫癜、動脈粥樣硬化、全身性紅斑狼瘡、用於自體移植之骨髓製備、移植排斥、腎小球性腎炎、間質性腎炎、狼瘡性腎炎、腎小管壞死、糖尿病性腎病變、腎肥大、第I型糖尿病、急性疼痛、發炎性疼痛、神經病變性疼痛、急性骨髓性白血病、黑色素瘤、多發性骨髓瘤、乳癌、前列腺癌、胰臟癌、肺癌、卵巢癌、神經膠質瘤、神經膠母細胞瘤、神經纖維瘤、溶骨性骨轉移、腦轉移、胃腸基質腫瘤及巨細胞瘤。
