The chemical molecule includes a multifunctional organism, including an anti-Mestolin antibody SS1P, a connector, an angry cutting field, a connector and a modified pseudopolygon A endocrine three-level functional control； pharmacodynamic synthesis； Nucleic acid； Vector； Clula Hugheside, Uses
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
PASTAN IRA H,WELDON JOHN,BEERS RICHARD
申请号：
CL2013003182
公开号：
CL2013003182A1
申请日:
2013.11.06
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to improved recombinant immunotoxins comprising anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and a Pseudomonas Exotoxin moiety which has been modified to reduce its immunogenicity and protease sensitivity and providing a better cytotoxicity for cells which express mesothelin. The RITs are well-suited for the treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.MOLÉCULA QUIMÉRICA QUE COMPRENDE UN POLIPÉPTIDO DE FUSIÓN QUE COMPRENDE El ANTICUERPO ANTI-MESOTELINA SS1P, UNA SECUENCIA ENLAZADORA, UN SITIO DE CORTE PARA FURINA, UNA SECUENCIA ENLAZADORA Y EL DOMINIO FUNCIONAL III DE UNA ENDOTOXINA A DE PSEUDOMONAS MODIFICADA (PE)； COMPOSICION FARMACÉUTICA； ÁCIDO NUCLEICO； VECTOR； CÉLULA HUÉSPED, USOS
