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PHARMACEUTICAL PRODUCT INCLUDING AN ADDITIVE LIQUID OF CULTURE OF MONONUCLEAR BLOOD CELLS
专利权人:
АПОСАЙЕНС АГ (AT)
发明人:
АНКЕРСМИТ Хендрик Ян (AT)
申请号:
RU2011129676/15
公开号:
RU2011129676A
申请日:
2009.12.18
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A topical pharmaceutical preparation for the treatment of inflammatory skin pathologies, preferably ischemia-related skin pathologies, containing saline supernatant obtained by culturing at least 1 hour peripheral blood mononuclear cells (PBMC) or a subpopulation thereof in physiological saline, free of substances promoting the proliferation of PBMCs and activating PBMCs. 2. The preparation according to claim 1, characterized in that said pathology is selected from the group of wounds, tissue ischemia, chronic wounds, diabetic wounds, external skin ulcers, skin burns, skin flaps in plastic surgery and tissue regeneration after dental implantation. The drug according to claim 1 or 2, characterized in that the subpopulation of peripheral blood mononuclear cells (PBMCs) is T cells, B cells or NK cells. The preparation according to claim 1 or 2, characterized in that the physiological saline is saline saline, preferably saline NaCl, whole blood, a blood fraction, preferably serum, or cell culture medium. The preparation according to claim 3, characterized in that the physiological saline is saline saline, preferably saline NaCl, whole blood, blood fraction, preferably serum, or cell culture medium. The preparation according to claim 4, characterized in that the medium for cell culture is selected from the group comprising RPMI medium, Eagle medium modified by the Dulbecco method (DMEM), X-vivo medium and Ultraculture medium. The drug according to claim 5, characterized in that the environment1. Фармацевтический препарат наружного применения для лечения воспалительных кожных патологий, предпочтительно кожной патологии, связанной с ишемией, содержащий надосадочную жидкость физиологического раствора, получаемую при культивировании по меньшей мере в течение 1 ч мононуклеарных клеток периферической крови (РВМС) или их субпопуляции в физиологическом растворе, свободном от веществ, способствующих пролиферации РВМС и активирующих РВМС.2. Препарат по п.1, характеризующийся те
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