It is intended to provide a technique of eliminating endotoxins, which are attached or adsorbed on the surface of solid articles such as medical instruments or instruments and apparatuses for producing medicines, by using a non-biological origin and sterilizable chemical reagent so as to eliminate the endotoxins at a high efficiency compared with the case of using water or physiological saline. Namely, compositions for eliminating endotoxins attached or adsorbed on solid surface characterized by containing as the active ingredient saccharides selected from the group consisting of monosaccharides, oligosaccharides, derivatives thereof and hydrates and salts of the same and a method of eliminating endotoxins from solid surface by bringing a solution of the composition as described above with the solid surface.
