PROBLEM TO BE SOLVED: To provide an anti-podopranin antibody which is a humanized antibody or a mouse-human chimeric antibody, or an antibody fragment containing an antigen-binding region thereof. An isolated anti-podopranin antibody or an antigen-binding region thereof, which is an isolated humanized antibody or mouse-human chimeric antibody, containing a predetermined amino acid sequence. [Selection diagram] Fig. 1【課題】ヒト化抗体若しくはマウス-ヒトキメラ抗体である抗ポドプラニン抗体又はその抗原結合領域を含む抗体断片の提供。【解決手段】所定のアミノ酸配列を含む、単離された、ヒト化抗体若しくはマウス-ヒトキメラ抗体である抗ポドプラニン抗体又はその抗原結合領域を含む抗体断片。【選択図】図1