DOYLE ANTHONY GERARD,JENNINGS PHILIP ANTHONY,POULTON LYNN DOROTHY,WAI BERNADETTE,POW ANDREW JAMES,CLARKE ADAM WILLAM
申请号：
TN2011000052
公开号：
TN2011000052A1
申请日:
2011.01.28
申请国别(地区):
TN
年份:
2012
代理人:
摘要：
The present invention provides an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80) and the antibody inhibits the binding of human IL-12 to human IL-12Rβ2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL- 12p80 to human IL-12Rβ1.
