DUAL-ACTING PHARMACEUTICAL COMPOSITIONS BASED ON SUPERSTRUCTURES OF ANGIOTENSIN RECEPTOR ANTAGONIST/BLOCKER (ARB) AND NEUTRAL ENDOPEPTIDASE (NEP) INHIBITOR
AL-FAYOUMI, SULIMAN,HU, JIAHUI,KUMARAPERUMAL, NATRAJAN,ROYCE, ALAN, EDWARD,RUEGGER, COLLEEN,ZANNOU, ERIKA AINA
申请号：
MYPI 2010001722
公开号：
MY153730A
申请日:
2008.11.04
申请国别(地区):
MY
年份:
2015
代理人:
摘要：
SOLID ORAL DOSAGE FORMS, ESPECIALLY TABLETS, OF A PHARMACEUTICAL COMPOSITION COMPRISING A SUPRAMOLECULAR COMPLEX CAN BE FORMED FROM A DIRECT COMPRESSION PROCESS OR A COMPACTION PROCESS SUCH AS ROLLER COMPACTION. SUCH SOLID ORAL DOSAGE FORMS FEATURE AN IMMEDIATE RELEASE PROFILE THAT ALLOWS FOR FAST RELEASE OF THE THERAPEUTIC AGENT. A PARTICULARLY USEFUL SUPRAMOLECULAR COMPLEX IS TRISODIUM [3-((1S,3R)-1-BIPHENYL-4-YLMETHYL-3-ETHOXYCARBONYL-1 -BUTYLCARBAMOYL) PROPIONATE-(S)-3’-METHYL-2’-(PENTANOYL{2’- (TETRAZOL-5-YLATE)BIPHENYL-4’-YLMETHYL}AMINO)BUTYRATE] HEMIPENTAHYDRATE.
