Ming-Jiu CHEN,Chung-Ming HSIEH,Jijie GU,Susan E. MORGAN-LAPPE,Yingchun LI
申请号：
US14798849
公开号：
US20160031986A1
申请日:
2015.07.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
