POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION;포항공과대학교 산학협력단;재단법인대구경북과학기술원;DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
HWANG, Il Doo,황일두,CHO, Hyun Woo,조현우,LEE, Sung Bae,이성배,CHO, Hyun Seob,조현섭
申请号：
KRKR2019/016419
公开号：
WO2020/111753A1
申请日:
2019.11.27
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a use of JULGI in diagnosing and treating guanine-quadruplex-related disease and, more particularly, to a guanine-quadruplex (G-quadruplex) detecting composition comprising JULGI protein or a protein having a homology of 80% or higher to the JULGI protein, a diagnostic composition comprising the detecting composition, a diagnostic kit comprising the diagnostic composition, a method for providing information for diagnosis of a neurodegenerative disease, cancer, or a viral infection disease which are in pathological correlation with G-quadruplex, and a pharmaceutical composition for prevention or treatment of a neurodegenerative disease, cancer, or a viral infection disease, the pharmaceutical composition comprising JULGI protein, a protein having a homology of 80% or more with the JULGI protein, or a mutant protein thereof. Thanks to the activity of binding to the G-quadruplex structure, JULGI according to the present invention is expected to be advantageously used in diagnosing or treating various diseases that are in pathological correlation with the abnormal formation and dissociation of the G-quadruplex structure.La présente invention concerne une utilisation de JULGI pour le diagnostic et le traitement d'une maladie liée à la guanine-quadruplex et, plus particulièrement, une composition de détection de guanine-quadruplex (G-quadruplex) comprenant la protéine JULGI ou une protéine ayant une homologie égale ou supérieure à 80 % à la protéine JULGI, une composition de diagnostic comprenant la composition de détection, un kit de diagnostic comprenant la composition de diagnostic, un procédé de fourniture d'informations de diagnostic d'une maladie neurodégénérative, d'un cancer ou d'une maladie à infection virale qui sont en corrélation pathologique avec la G-quadruplex, et une composition pharmaceutique de prévention ou de traitement d'une maladie neurodégénérative, d'un cancer, ou d'une maladie à infection virale, la composition pha
