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Thienopyridine derivatives and their use as modulators of HSP90
- 专利权人:
- MERCK PATENT GMBH
- 发明人:
- EGGENWEILER, HANS-MICHAEL,WOLF, MICHAEL
- 申请号：
- ES06706808
- 公开号：
- ES2462923T3
- 申请日:
- 2006.02.10
- 申请国别(地区):
- ES
- 年份:
- 2014
- 代理人:
- 摘要：
- Compounds selected from the group 2-aminocarbonyl-3, 6-diamino-5-cyano-4- (3, 4-dimethoxy-phenyl) -thieno [2,3-b] pyridine ("A1"), 2-aminocarbonyl-3 , 6-diamino-5-cyano-4- (2, 4-dimethoxy-phenyl) -thieno [2,3-b] pyridine ("A2"), 2-aminocarbonyl-3, 6-diamino-5-cyano- 4- (2, 5-dimethoxy-phenyl) -thieno [2,3-b] pyridine ("A2a"), 2-aminocarbonyl-3, 6-diamino-5-cyano-4- (2, 3-dimethoxy- phenyl) -thieno [2,3-b] pyridine ("A2b"), 2-aminocarbonyl-3, 6-diamino-5-cyano-4- (3-hydroxy-4-methoxyphenyl) -thieno [2, 3- b] pyridine ("A3"), 2-aminocarbonyl-3, 6-diamino-5-cyano-4- (2, 4, 5-trimethoxyphenyl) -thieno [2,3-b] pyridine ("A5"), 2-aminocarbonyl-3,6-diamino-5-cyano-4- (2,3,4-trimethoxyphenyl) -thieno [2,3-b] pyridine ("A6"), 2-aminocarbonyl-3,6-diamino -5-cyano-4- (3-hydroxy-phenyl) -thieno [2,3-b] pyridine ("A8a"), 2-aminocarbonyl-3, 6-diamino-5-cyano-4- (3-hydroxy -4-trifluoromethoxy-phenyl) -thieno [2,3-b] pyridine ("A8b"), 2-aminocarbonyl-3, 6-diamino-5-cyano-4- (3-hydroxy-4-methylsulfanyl-phenyl) -thieno [2,3-b] pyridine ("A8c"), 2- ((N-methyl-aminocarbonyl) -3,6-diamino-5-cyano-4- (3-hydroxy-4-methoxy-phenyl) -thieno [2,3-b] pyridine ("A8h"), 2- ((N-methyl-aminocarbonyl) -3,6-diamino-5-cyano-4- (3-hydroxyphenyl) -thieno [2,3-b] pyridine ("A8i"), 2- ((N- methyl-aminocarbonyl) -3,6-diamino-5-cyano-4- (3-hydroxy-4-trifluoromethoxy-phenyl) -thieno [2,3-b] pyridine ("A8j"), 2- ((N- methyl-aminocarbonyl) -3,6-diamino-5-cyano-4- (3-hydroxy-4-methylsulfanyl-phenyl) -thieno [2,3-b] pyridine ("A8k"), 2-aminocarbonyl-3, 6-diamino-5-cyano-4- (3-hydroxy-4, 5-dimethoxy-phenyl) -thieno [2,3-b] pyridine ("A8l"), 2-aminocarbonyl-3, 6-diamino-5 -cyano-4- (2-bromo-5-hydroxyphenyl) -thieno [2,3-b] pyridine ("A8m"), 2-aminocarbonyl-3, 6-diamino-5-cyano-4- (4- difluoromethoxy-3-hydroxy-phenyl) -thieno [2,3-b] pyridine ("A8n"), 2-aminocarbonyl-3, 6-diamino-5-cyano-4- (4-methyl-3-hydroxyphenyl) - thieno [2,3-b] pyridine ("A8 °"), 2-aminocarbonyl-3, 6-diamino-5-cyano-4- [3- (5-ethoxycarbonyl-
- 来源网站：
- 中国工程科技知识中心
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- http://www.ckcest.cn/home/
