METHOD FOR PRODUCING DISINTEGRATING PARTICULATE COMPOSITION COMPRISING ACID TYPE CARBOXYMETHYLCELLULOSE DISINTEGRATING PARTICULATE COMPOSITION COMPRISING ACID TYPE CARBOXYMETHYLCELLULOSE AND ORALLY DISINTEGRATING TABLET INCLUDING DISINTEGRATING PARTICULATE COMPOSITION COMPRISING ACID TYPE CARBOXYMETHYLCELLULOSE
The purpose of the present application is to provide an orally disintegrating tablet having excellent tablet hardness and disintegrating performance a disintegrating particulate composition by which the orally disintegrating tablet is obtained with relatively low tablet compression force and which is able to impart excellent moldability a method for producing the same and the like. The present application pertains to: a method for producing a disintegrating particulate composition including the three components of a first disintegrating tablet component comprising acid type carboxymethylcellulose a second disintegrating tablet component and an excipient wherein the method includes a first wet granulation step for using any two components of the three components and a second wet granulation step for using the granulated material obtained in the first wet granulation step and the remaining one component of the three components； a production method further including crystalline cellulose as a fourth component； a production method comprising a third step for mixing crystalline cellulose into the granulated material obtained in the second wet granulation step； disintegrating particulate compositions obtained by these production methods； and the like.
