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COMBINED VACCINE WITH ACELLULAR PERFECT
专利权人:
Панацеа Биотек Лтд. (IN)
发明人:
ДЖАИН Раджеш (IN),СИНГХ Сукхджит (IN),ЖДАМБУ Лавит (IN)
申请号:
RU2013101418/10
公开号:
RU2013101418A
申请日:
2013.01.14
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A fully liquid stable combination vaccine comprising diphtheria (D), tetanus (T), acellular pertussis (aP), Haemophilus influenzae (Hib) and poliovirus (IPV) antigens, where D, T and aP antigens are adsorbed on aluminum phosphate, Hep the antigen is adsorbed on aluminum hydroxide and the Hib antigen is conjugated to a carrier protein selected from the group consisting of tetanus toxoid, diphtheria toxoid, CRM 197 and the outer membrane protein of Neisseria meningitides or any equivalents thereof, and where further IPV antigens are presented myself Sa lk strains selected from the group Mahoney type 1, MEF type 2 and Saukett type 3, or Sabin strains selected from the group Sabin 1 or 2 and aP include at least one antigen from the group comprising pertussis toxoid (PT), filamentous hemagglutinin (FHA), pertactin (P69 or PRN) and fimbrial proteins (FIM 1,2 and 3) .2. The vaccine according to claim 1, wherein the Hib antigen is not substantially adsorbed on any adjuvant. The vaccine according to claim 1, wherein the Hib antigen is obtained from the capsular polysaccharide of the Hib b strain. The vaccine according to claim 1, wherein the Hep antigen is obtained from the surface antigen of the Hep B strain. The vaccine according to claim 1, including D, T, aP (PT, FHA, PRN), Hib b, Hep B and IPV (Mahoney type 1, MEF type 2 and Saukett type 3), where D is present in an amount of from about 1 to 40 Lf, T is present in an amount of from about 1 to 25 Lf, PT is present in an amount of from about 1 to 40 μg, FHA is present in an amount of from about 1 to 40 μg, and PRN is present in an amount of from about 1 to 15 μg per 0.5 ml, Hib b is present in an amount of about 1 to 20 μg and Hep B is present in an amount of about 1 to 25 μg per 0.5 ml and the Mahoney strains type 1, MEF type 2 and Saukett type 3 are present comfort in an amount of Approximate1. Полностью жидкая стабильная комбинированная вакцина, включающая антигены дифтерии (D), столбняка (Т), ацеллюлярного коклюша
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中国工程科技知识中心
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