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Method for producing sulfonyl chloride compound
专利权人:
发明人:
Keisuke Majima
申请号:
US15266307
公开号:
US09932322B2
申请日:
2016.09.15
申请国别(地区):
US
年份:
2018
代理人:
摘要:
An object of the present invention is to provide a production method of an intermediate used in the production method of a sulfonylpyrrole compound useful as a pharmaceutical product. The present invention relates to a method of producing sulfonylpyrrole compound (VI) by reacting a pyridine-3-sulfonic acid compound with phosphorus pentachloride in a solvent of chlorobenzene or trifluoromethylbenzene to give a pyridine-3-sulfonyl chloride compound, reacting the compound without isolation with compound (III) to give compound (IV), and subjecting the compound (IV) to a reductive amination reaction.wherein R2 is a hydrocarbon group etc. and R3 and R4 are each a hydrogen atom etc.,wherein R1 is an optionally substituted pyridin-3-yl group, and the other symbols are as defined above,wherein R5 is an alkyl group and the other symbols are as defined above.
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