HRUPKA, BRIAN JOEL,LINDERS, JOANNES THEODORUS MARIA,ROEVENS, PETER WALTER MARIA
申请号：
PE0021632013
公开号：
PE05722014A1
申请日:
2009.06.03
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to a Pharmaceutical Combination comprising: a) an agonist of peroxisome proliferators activated receptors (PPAR) in particular PPAR - as a Group and (b) an inhibitor of acyl coa diacylglycerol acyltransferase (DGAT) such as 4 - [[4 - [2-chloro-4 - (1 - pirrolidinilmetil) fe Nile] acetyl] - 1-piperazinyl] - N - [3 - (1 - pirrolidinil) phenyl] - benzamide 4 - [4 - [[26 - Dichloro - 4 - (1 - pirrolidinilmetil) phenyl] acetyl] - 1-piperazinyl] - N - [3 - (1 - pirrolidinil) phenyl] - benzamide 4 - [4 - [[2,6-dichloro-4 - [[4 - (methylsulfonyl) - 1-piperazinyl] methyl] phenyl] acetyl] - 1-piperazinyl] - n - [3 - (1 - pirrolidinil) phenyl] - benzamide among others. This combination is useful for the treatment of Hypercholesterolemia, hyperlipidemia, obesity, Type 2 diabetes, fatty liverSE REFIERE A UNA COMBINACION FARMACEUTICA QUE COMPRENDE: A) UN AGONISTA DE RECEPTORES ACTIVADOS POR PROLIFERADORES DE PEROXISOMA (PPAR) EN PARTICULAR PPAR-a TAL COMO UN FENOFIBRATO Y B) UN INHIBIDOR DE ACIL CoA DIACILGLICEROL ACILTRANSFERASA (DGAT) TAL COMO 4-[4-[[2-CLORO-4-(1-PIRROLIDINILMETIL)FENILO]ACETIL]-1-PIPERAZINIL]-N-[3-(1-PIRROLIDINIL)FENIL]-BENZAMIDA 4-[4-[[2,6-DICLORO-4-(1-PIRROLIDINILMETIL)FENIL]ACETIL]-1-PIPERAZINIL]-N-[3-(1-PIRROLIDINIL)FENIL]-BENZAMIDA 4-[4-[[2,6-DICLORO-4-[[4-(METILSULFONIL)-1-PIPERAZINIL]METIL]FENIL]ACETIL]-1-PIPERAZINIL]-N-[3-(1-PIRROLIDINIL)FENIL]-BENZAMIDA ENTRE OTROS. DICHA COMBINACION ES UTIL PARA EL TRATAMIENTO DE OBESIDAD, HIPERCOLESTEROLEMIA, HIPERLIPIDEMIA, DIABETES TIPO 2, HIGADO GRASO
